John Michael O'Brien Jr.

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john.obrien2@uky.edu

(859) 323-6434

800 Rose Street Lexington, KY 40356

Position(s):

Professor

MFM Division Director

Co-Director OMNI Service Line

Affiliation(s):

Obstetrics & Gynecology

Other Affiliation(s):

Maternal Fetal Medicine

Bio / Education:

Jan. 1, 2011, Dr. O’Brien officially joined UK HealthCare Women’s Health Obstetrics and Gynecology as the new director of Maternal Fetal Medicine.

Dr. O’Brien is board certified in obstetrics and gynecology and maternal-fetal medicine. He comes to UK HealthCare from Central Baptist Hospital where he was the director of the Perinatal Diagnostic Center for the past 16 years. During his time at Central Baptist, he chaired peer review for Obstetrics and Gynecology, was involved in the March of Dimes Prematurity Prevention Steering Committee, the State of Kentucky Birth Defect Surveillance Registry Advisory Committee, and served on the board of directors of the Kentucky Perinatal Association.

After graduating from Wayne State University School of Medicine in Detroit, Dr. O’Brien participated in the Wayne State University Affiliate Hospital Program where he completed his internship and residency. He went on to pursue a fellowship in maternal-fetal medicine at the University of Tennessee in Memphis.

Dr. O’Brien is a member of several professional organizations. His interests include fetal diagnosis of malformations and preterm birth prevention with the use of progesterone.

Selected Publications:

American Journal of Obstetrics and Gynecology 2016

PubMed Publications:

Reynolds, LJ ; Chavan, NR ; DeHoff, LB ; Preston, JD ; Maddox, HF ; O'Brien, JM ; Armstrong, DA ; Marsit, CJ ; Pearson, KJ "Smoking during pregnancy increases chemerin expression in neonatal tissue." Experimental physiology 104, 1 (2019): 93-99. [PubMed Link] | [ Full text ]
Conde-Agudelo, A.; Romero, R.; Da Fonseca, E.; O'Brien, JM ; Cetingoz, E.; Creasy, GW ; Hassan, SS ; Erez, O.; Pacora, P.; Nicolaides, KH "Vaginal progesterone is as effective as cervical cerclage to prevent preterm birth in women with a singleton gestation, previous spontaneous preterm birth, and a short cervix: updated indirect comparison meta-analysis." American journal of obstetrics and gynecology 219, 1 (2018): 10-25. [PubMed Link] | [ Full text ]
O'Brien, JM "Personalised medicine-the potential yet realised." BJOG : an international journal of obstetrics and gynaecology 125, 3 (2018): 351. [PubMed Link] | [ Full text ]
Romero, R.; Conde-Agudelo, A.; Da Fonseca, E.; O'Brien, JM ; Cetingoz, E.; Creasy, GW ; Hassan, SS ; Nicolaides, KH "Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in singleton gestations with a short cervix: a meta-analysis of individual patient data." American journal of obstetrics and gynecology 218, 2 (2018): 161-180. [PubMed Link] | [ Full text ]
Reynolds, LJ ; Pollack, RI ; Charnigo, RJ ; Rashid, CS ; Stromberg, AJ ; Shen, S.; O'Brien, JM ; Pearson, KJ "Increased birth weight is associated with altered gene expression in neonatal foreskin." Journal of developmental origins of health and disease 8, 5 (2017): 575-583. [PubMed Link] | [ Full text ]
O'Brien, JM "Vaginal progesterone prophylaxis for preterm birth." Lancet (London, England) 388, 10050 (2016): 1159-60. [PubMed Link] | [ Full text ]
O'Brien, JM "Re: Long-term effects of prenatal progesterone exposure: neurophysiological development and hospital admissions in twins up to 8 years of age. C. Vedel, H. Larsen, A. Holmskov, K. R. Andreasen, N. Uldbjerg, J. Ramb, B. Bødker, L. Skibsted, L...." Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 48, 3 (2016): 284. [PubMed Link] | [ Full text ]
Romero, R.; Nicolaides, KH ; Conde-Agudelo, A.; O'Brien, JM ; Cetingoz, E.; Da Fonseca, E.; Creasy, GW ; Hassan, SS "Vaginal progesterone decreases preterm birth ≤ 34 weeks of gestation in women with a singleton pregnancy and a short cervix: an updated meta-analysis including data from the OPPTIMUM study." Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 48, 3 (2016): 308-17. [PubMed Link] | [ Full text ]
O'Brien, JM "Can history repeat itself? Improved assessment of the best biomarker is the first step." BJOG : an international journal of obstetrics and gynaecology 123, 6 (2016): 885. [PubMed Link] | [ Full text ]
O'Brien, JM ; Lewis, DF "Prevention of preterm birth with vaginal progesterone or 17-alpha-hydroxyprogesterone caproate: a critical examination of efficacy and safety." American journal of obstetrics and gynecology 214, 1 (2016): 45-56. [PubMed Link] | [ Full text ]
O'Brien, JM "Progestogen safety in multiple gestations: application of the Bradford Hill criteria." BJOG : an international journal of obstetrics and gynaecology 122, 5 (2015): 610-4. [PubMed Link] | [ Full text ]
Pearce, CF ; Lain, K.; Hansen, WF ; Curry T, Jr ; O'Brien, JM "The use of digital peripheral artery tonometry to detect endothelial dysfunction in pregnant women who smoke." American journal of perinatology 31, 2 (2014): 113-8. [PubMed Link] | [ Full text ]
O'Brien, JM "Medication safety is still an issue in obstetrics 50 years after the Kefauver-Harris amendments: the case of progestogens." Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 42, 3 (2013): 247-53. [PubMed Link] | [ Full text ]
Garabedian, MJ ; Hansen, WF ; McCord, LA ; Manning, MA ; O'Brien, JM ; Curry TE, Jr "Up-regulation of oxytocin receptor expression at term is related to maternal body mass index." American journal of perinatology 30, 6 (2013): 491-7. [PubMed Link] | [ Full text ]
O'Brien, JM "The safety of progesterone and 17-hydroxyprogesterone caproate administration for the prevention of preterm birth: an evidence-based assessment." American journal of perinatology 29, 9 (2012): 665-72. [PubMed Link] | [ Full text ]
O'Brien, JM ; Whetham, D.; Fecteau, C.; Jansen, J.; Hiles, M. "Augmenting myometrial healing after cesarean delivery: use of an adjuvant biologic graft placement in an ovine model." American journal of perinatology 28, 7 (2011): 543-50. [PubMed Link] | [ Full text ]
O'Brien, JM ; Lewis, DF "Progestins for the prevention of spontaneous preterm birth: review and implications of recent studies." The Journal of reproductive medicine 54, 2 (2009): 73-87. [PubMed Link] |
O'Brien, JM ; Adair, CD ; Lewis, DF ; Hall, DR ; Defranco, EA ; Fusey, S.; Soma-Pillay, P.; Porter, K.; How, H.; Schackis, R.; Eller, D.; Trivedi, Y.; Vanburen, G ; Khandelwal, M.; Trofatter, K.; Vidyadhari, D.; Vijayaraghavan, J.; Weeks, J.; Dattel, B.; Newton, E.; Chazotte, C.; Valenzuela, G.; Calda, P.; Bsharat, M.; Creasy, GW "Progesterone vaginal gel for the reduction of recurrent preterm birth: primary results from a randomized, double-blind, placebo-controlled trial." Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 30, 5 (2007): 687-96. [PubMed Link] | [ Full text ]
Nelson, WL ; O'Brien, JM "The uterine sandwich for persistent uterine atony: combining the B-Lynch compression suture and an intrauterine Bakri balloon." American journal of obstetrics and gynecology 196, 5 (2007): e9-10. [PubMed Link] | [ Full text ]
Day, MC ; Barton, JR ; O'Brien, JM ; Istwan, NB ; Sibai, BM "The effect of fetal number on the development of hypertensive conditions of pregnancy." Obstetrics and gynecology 106, 5 Pt 1 (2005): 927-31. [PubMed Link] |
Lombardi, DG ; Barton, JR ; O'Brien, JM ; Istwan, NK ; Sibai, BM "Does an obese prepregnancy body mass index influence outcome in pregnancies complicated by mild gestational hypertension remote from term?" American journal of obstetrics and gynecology 192, 5 (2005): 1472-4. [PubMed Link] | [ Full text ]
Schwendemann, WD ; O'Brien, JM ; Barton, JR ; Milligan, DA ; Istwan, N. "Modifiable risk factors for growth restriction in twin pregnancies." American journal of obstetrics and gynecology 192, 5 (2005): 1440-2. [PubMed Link] | [ Full text ]
O'Brien, JM ; Barton, JR "Controversies with the diagnosis and management of HELLP syndrome." Clinical obstetrics and gynecology 48, 2 (2005): 460-77. [PubMed Link] | [ Full text ]
Lombardi, DG ; Istwan, NB ; Rhea, DJ ; O'Brien, JM ; Barton, JR "Measuring outpatient outcomes of emesis and nausea management in pregnant women." Managed care (Langhorne, Pa.) 13, 11 (2004): 48-52. [PubMed Link] | [ Full text ]
Cottrill, HM ; Barton, JR ; O'Brien, JM ; Rhea, DL ; Milligan, DA "Factors influencing maternal perception of uterine contractions." American journal of obstetrics and gynecology 190, 5 (2004): 1455-7. [PubMed Link] | [ Full text ]
O'Brien, JM ; Hill, AL ; Barton, JR "Funneling to the stitch: an informative ultrasonographic finding after cervical cerclage." Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 20, 3 (2002): 252-5. [PubMed Link] | [ Full text ]
Barton, CB ; Barton, JR ; O'Brien, JM ; Bergauer, NK ; Sibai, BM "Mild gestational hypertension: differences in ethnicity are associated with altered outcomes in women who undergo outpatient treatment." American journal of obstetrics and gynecology 186, 5 (2002): 896-8. [PubMed Link] | [ Full text ]
Bush, KD ; O'Brien, JM ; Barton, JR "The utility of umbilical artery Doppler investigation in women with the HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome." American journal of obstetrics and gynecology 184, 6 (2001): 1087-9. [PubMed Link] | [ Full text ]
Barton, JR ; O'Brien, JM ; Bergauer, NK ; Jacques, DL ; Sibai, BM "Mild gestational hypertension remote from term: progression and outcome." American journal of obstetrics and gynecology 184, 5 (2001): 979-83. [PubMed Link] | [ Full text ]
Ford, RF ; Barton, JR ; O'Brien, JM ; Hollingsworth, PW "Demographics, management, and outcome of peripartum cardiomyopathy in a community hospital." American journal of obstetrics and gynecology 182, 5 (2000): 1036-8. [PubMed Link] | [ Full text ]
O'Brien, JM ; Allen, AA ; Barton, JR "Intravaginal saline as a contrast agent for cervical sonography in the obstetric patient." Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 13, 2 (1999): 137-9. [PubMed Link] | [ Full text ]