Christopher Philip Desimone

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Christopher.DeSimone@uky.edu
859-257-3428
331B Whitney Hendrickson Bldg

Position(s):

Clinical Faculty

Professor

Associate Chief Medical Officer, Peri-operative Services

Listed in Best Doctors in America

Director of Robotic-assisted Surgery

Affiliation(s):

Obstetrics & Gynecology

Other Affiliation(s):

Gynecologic Oncology

Bio / Education:

Dr. DeSimone attended Boston University and the University of Kentucky School of Medicine. He is board certified in Obstetrics and Gynecology and the subspecialty of Gynecologic Oncology. His current research in ovarian cancer is a combined project with the Department of Dentistry. The NCI-funded study explores the genetic association between women with hypodontia (congenitally missing teeth) and epithelial ovarian cancer. Dr. DeSimone is also involved with several national clinical trials utilizing chemotherapy for the treatment of ovarian cancer. He is the director of UK HealthCare’s Robotic-assisted Surgery Program.

PubMed Publications:

More, R.;Chen, Q.;Desimone, C.P.;Miller, R.W.;Baldwin, L.A.;Nagell JR, J.;Huang, B.;Tucker, T.C.;Johnson, M.S.;Fredericks, T.I.;Ueland, F.R. "Population-Based Analysis of Patient Age and Other Disparities in the Treatment of Ovarian Cancer in Central Appalachia and Kentucky." Southern medical journal 111, 6 (2018): 333-341. [PubMed Link] | [ Full text ]
Baldwin, L.A.;Pavlik, E.J.;Ueland, E.;Brown, H.E.;Ladd, K.M.;Huang, B.;Desimone, C.P.;Van Nagell, J.R.;Ueland, F.R.;Miller, R.W. "Complications from Surgeries Related to Ovarian Cancer Screening." Diagnostics (Basel, Switzerland) 7, 1 (2017): [PubMed Link] | [ Full text ]
More, R.;Baldwin, L.;Woolum, D.;Elliott, E.;Wijers, C.;Chen, C.Y.;Miller, R.W.;Desimone, C.P.;Ueland, F.R.;Kryscio, R.J.;Nagell, J.R.;Pavlik, E.J. "Symptoms Relevant to Surveillance for Ovarian Cancer." Diagnostics (Basel, Switzerland) 7, 1 (2017): [PubMed Link] | [ Full text ]
Lefringhouse, J.R.;Elder, J.W.;Baldwin, L.A.;Miller, R.W.;Desimone, C.P.;Nagell JR, J.;Samoyoa, L.M.;West, D.S.;Dressler, E.V.;Liu, M.;Ueland, F.R. "Prospective validation of an intraoperative algorithm to guide surgical staging in early endometrial cancer." Gynecologic oncology 145, 1 (2017): 50-54. [PubMed Link] | [ Full text ]
Lefringhouse, J.R.;Neward, E.;Ueland, F.R.;Baldwin, L.A.;Miller, R.W.;Desimone, C.P.;Kryscio, R.J.;Van Nagell, J.R.;Pavlik, E.J. "Probability of fallopian tube and ovarian detection with transvaginal ultrasonography in normal women." Women's health (London, England) 12, 3 (2016): 303-11. [PubMed Link] | [ Full text ]
Edwards, A.M.;Edwards, J.;Baldwin, L.A.;Desimone, C.P. "Does Vaginal Cuff Length After Radical Hysterectomy Predict a Localized Recurrence of Cervical Cancer? 236 ." Obstetrics and gynecology 125 Suppl 1, (2015): 76S. [PubMed Link] | [ Full text ]
Elder, J.W.;Pavlik, E.J.;Long, A.;Miller, R.W.;Desimone, C.P.;Hoff, J.T.;Ueland, W.R.;Kryscio, R.J.;Nagell JR, J.;Ueland, F.R. "Serial ultrasonographic evaluation of ovarian abnormalities with a morphology index." Gynecologic oncology 135, 1 (2014): 8-12. [PubMed Link] | [ Full text ]
Pavlik, E.J.;Ueland, F.R.;Miller, R.W.;Ubellacker, J.M.;Desimone, C.P.;Elder, J.;Hoff, J.;Baldwin, L.;Kryscio, R.J.;Nagell JR, J. "Frequency and disposition of ovarian abnormalities followed with serial transvaginal ultrasonography." Obstetrics and gynecology 122, 2 Pt 1 (2013): 210-7. [PubMed Link] | [ Full text ]
Baldwin, L.A.;Huang, B.;Miller, R.W.;Tucker, T.;Goodrich, S.T.;Podzielinski, I.;Desimone, C.P.;Ueland, F.R.;Van Nagell, J.R.;Seamon, L.G. "Ten-year relative survival for epithelial ovarian cancer." Obstetrics and gynecology 120, 3 (2012): 612-8. [PubMed Link] | [ Full text ]
McDonald, J.M.;Karabakhtsian, R.G.;Pierce, H.H.;Iocono, J.A.;Desimone, C.P.;Bayliff, S.L.;Ueland, F.R. "Small cell carcinoma of the ovary of hypercalcemic type: a case report." Journal of pediatric surgery 47, 3 (2012): 588-92. [PubMed Link] | [ Full text ]
Arora, R.;Eble, J.N.;Pierce, H.H.;Crispen, P.L.;Desimone, C.P.;Lee, E.Y.;Karabakhtsian, R.G. "Bilateral ovarian steroid cell tumours and massive macronodular adrenocortical disease in a patient with hereditary leiomyomatosis and renal cell cancer syndrome." Pathology 44, 4 (2012): 360-3. [PubMed Link] |
Desimone, C.P.;Day, M.E.;Dietrich CS, 3rd;Tovar, M.M.;Modesitt, S.C. "Risk for residual adenocarcinoma in situ or cervical adenocarcinoma in women undergoing loop electrosurgical excision procedure/conization for adenocarcinoma in situ." The Journal of reproductive medicine 56, 9-10 (2011): 376-80. [PubMed Link] |
Ueland, F.R.;Desimone, C.P.;Seamon, L.G.;Miller, R.A.;Goodrich, S.;Podzielinski, I.;Sokoll, L.;Smith, A.;Nagell JR, J.;Zhang, Z. "Effectiveness of a multivariate index assay in the preoperative assessment of ovarian tumors." Obstetrics and gynecology 117, 6 (2011): 1289-97. [PubMed Link] | [ Full text ]
Ware Miller, R.;Smith, A.;Desimone, C.P.;Seamon, L.;Goodrich, S.;Podzielinski, I.;Sokoll, L.;Nagell JR, J.;Zhang, Z.;Ueland, F.R. "Performance of the American College of Obstetricians and Gynecologists' ovarian tumor referral guidelines with a multivariate index assay." Obstetrics and gynecology 117, 6 (2011): 1298-306. [PubMed Link] | [ Full text ]
Nagell JR, J.;Miller, R.W.;Desimone, C.P.;Ueland, F.R.;Podzielinski, I.;Goodrich, S.T.;Elder, J.W.;Huang, B.;Kryscio, R.J.;Pavlik, E.J. "Long-term survival of women with epithelial ovarian cancer detected by ultrasonographic screening." Obstetrics and gynecology 118, 6 (2011): 1212-21. [PubMed Link] | [ Full text ]
Seamon, L.G.;Tarrant, R.L.;Fleming, S.T.;Vanderpool, R.C.;Pachtman, S.;Podzielinski, I.;Branscum, A.J.;Feddock, J.M.;Randall, M.E.;Desimone, C.P. "Cervical cancer survival for patients referred to a tertiary care center in Kentucky." Gynecologic oncology 123, 3 (2011): 565-70. [PubMed Link] | [ Full text ]
Desimone, C.P.;Elder, J.;Nagell JR, J. "Selective inguinal lymphadenectomy in the treatment of invasive squamous cell carcinoma of the vulva." International journal of surgical oncology 2011, (2011): 284374. [PubMed Link] | [ Full text ]
Saunders, B.A.;Podzielinski, I.;Ware, R.A.;Goodrich, S.;Desimone, C.P.;Ueland, F.R.;Seamon, L.;Ubellacker, J.;Pavlik, E.J.;Kryscio, R.J.;Nagell JR, J. "Risk of malignancy in sonographically confirmed septated cystic ovarian tumors." Gynecologic oncology 118, 3 (2010): 278-82. [PubMed Link] | [ Full text ]
Ferriss, J.S.;Brix, W.;Tambouret, R.;Desimone, C.P.;Stoler, M.;Modesitt, S.C. "Cervical stromal invasion predicting survival in endometrial cancer." Obstetrics and gynecology 116, 5 (2010): 1035-41. [PubMed Link] | [ Full text ]
Dietrich CS, 3rd;Greenberg, V.L.;Desimone, C.P.;Modesitt, S.C.;Van Nagell, J.R.;Craven, R.;Zimmer, S.G. "Suberoylanilide hydroxamic acid (SAHA) potentiates paclitaxel-induced apoptosis in ovarian cancer cell lines." Gynecologic oncology 116, 1 (2010): 126-30. [PubMed Link] | [ Full text ]
McDonald, J.M.;Doran, S.;Desimone, C.P.;Ueland, F.R.;DePriest, P.D.;Ware, R.A.;Saunders, B.A.;Pavlik, E.J.;Goodrich, S.;Kryscio, R.J.;Nagell JR, J. "Predicting risk of malignancy in adnexal masses." Obstetrics and gynecology 115, 4 (2010): 687-94. [PubMed Link] | [ Full text ]
Coker, A.L.;Desimone, C.P.;Eggleston, K.S.;White, A.L.;Williams, M. "Ethnic disparities in cervical cancer survival among Texas women." Journal of women's health (2002) 18, 10 (2009): 1577-83. [PubMed Link] |
Coker, A.L.;Desimone, C.P.;Eggleston, K.S.;Hopenhayn, C.;Nee, J.;Tucker, T. "Smoking and survival among Kentucky women diagnosed with invasive cervical cancer: 1995-2005." Gynecologic oncology 112, 2 (2009): 365-9. [PubMed Link] | [ Full text ]
Pavlik, E.J.;Saunders, B.A.;Doran, S.;McHugh, K.W.;Ueland, F.R.;Desimone, C.P.;DePriest, P.D.;Ware, R.A.;Kryscio, R.J.;Nagell JR, J. "The search for meaning-Symptoms and transvaginal sonography screening for ovarian cancer: predicting malignancy." Cancer 115, 16 (2009): 3689-98. [PubMed Link] | [ Full text ]
Coker, A.L.;Hopenhayn, C.;Desimone, C.P.;Bush, H.M.;Crofford, L. "Violence against Women Raises Risk of Cervical Cancer." Journal of women's health (2002) 18, 8 (2009): 1179-85. [PubMed Link] |
Chalothorn, L.A.;Beeman, C.S.;Ebersole, J.L.;Kluemper, G.T.;Hicks, E.P.;Kryscio, R.J.;Desimone, C.P.;Modesitt, S.C. "Hypodontia as a risk marker for epithelial ovarian cancer: a case-controlled study." Journal of the American Dental Association (1939) 139, 2 (2008): 163-9. [PubMed Link] | [ Full text ]
Desimone, C.P.;Ueland, F.R. "Gynecologic laparoscopy." The Surgical clinics of North America 88, 2 (2008): 319-41, vi. [PubMed Link] | [ Full text ]
Nagell JR, J.;DePriest, P.D.;Ueland, F.R.;Desimone, C.P.;Cooper, A.L.;McDonald, J.M.;Pavlik, E.J.;Kryscio, R.J. "Ovarian cancer screening with annual transvaginal sonography: findings of 25,000 women screened." Cancer 109, 9 (2007): 1887-96. [PubMed Link] | [ Full text ]
Desimone, C.P. "Cervical cancer, human papillomavirus and smoking." The Journal of the Kentucky Medical Association 105, 5 (2007): 212-4. [PubMed Link] |
Dietrich CS, 3rd;Desimone, C.P.;Modesitt, S.C.;DePriest, P.D.;Ueland, F.R.;Pavlik, E.J.;Kryscio, R.;Cibull, M.;Huh, W.;Partridge, E.;Numnum, T.M.;Schilder, J.;Higgins, R.V.;Nagell JR, 2nd "Primary appendiceal cancer: gynecologic manifestations and treatment options." Gynecologic oncology 104, 3 (2007): 602-6. [PubMed Link] | [ Full text ]
Desimone, C.P.;Van Ness, J.S.;Cooper, A.L.;Modesitt, S.C.;DePriest, P.D.;Ueland, F.R.;Pavlik, E.J.;Kryscio, R.J.;Nagell JR, J. "The treatment of lateral T1 and T2 squamous cell carcinomas of the vulva confined to the labium majus or minus." Gynecologic oncology 104, 2 (2007): 390-5. [PubMed Link] | [ Full text ]
Desimone, C.P.;Day, M.E.;Tovar, M.M.;Dietrich CS, 3rd;Eastham, M.L.;Modesitt, S.C. "Rate of pathology from atypical glandular cell Pap tests classified by the Bethesda 2001 nomenclature." Obstetrics and gynecology 107, 6 (2006): 1285-91. [PubMed Link] |
Desimone, C.P.;Crisp, M.P.;Ueland, F.R.;DePriest, P.D.;Van Nagell, J.R.;Lele, S.M.;Modesitt, S.C. "Concordance of gross surgical and final fixed margins in vulvar intraepithelial neoplasia 3 and vulvar cancer." The Journal of reproductive medicine 51, 8 (2006): 617-20. [PubMed Link] |
Ueland, F.R.;DePriest, P.D.;Desimone, C.P.;Pavlik, E.J.;Lele, S.M.;Kryscio, R.J.;Nagell JR, J. "The accuracy of examination under anesthesia and transvaginal sonography in evaluating ovarian size." Gynecologic oncology 99, 2 (2005): 400-3. [PubMed Link] | [ Full text ]
Chobanian, N.H.;Greenberg, V.L.;Gass, J.M.;Desimone, C.P.;Van Nagell, J.R.;Zimmer, S.G. "Histone deacetylase inhibitors enhance paclitaxel-induced cell death in ovarian cancer cell lines independent of p53 status." Anticancer research 24, 2B (2004): 539-45. [PubMed Link] | [ Full text ]
DePriest, P.D.;Desimone, C.P. "Ultrasound screening for the early detection of ovarian cancer." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 21, 10 Suppl (2003): 194s-199s. [PubMed Link] | [ Full text ]
Desimone, C.P.;Lele, S.M.;Modesitt, S.C. "Malignant struma ovarii: a case report and analysis of cases reported in the literature with focus on survival and I131 therapy." Gynecologic oncology 89, 3 (2003): 543-8. [PubMed Link] | [ Full text ]